Highly diastereoselective synthesis of propargylic 1,2-anti-diol derivatives using α-alkoxypropargylstannanes

被引：26

作者：

Savall, BM ^{[1
]}

Powell, NA ^{[1
]}

Roush, WR ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 19期

关键词：

D O I：

10.1021/ol016536m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Propargylic 1,2-anti-diol derivatives 2 and 10 are prepared in high yield and excellent diastereoselectivity by addition of alpha -alkoxypropargyl-stannanes 4a and 4b to aldehydes in the presence of BuSnCl3. We also introduce the use of KF on Celite as a convenient and mild reagent for removal of the organotin waste products of these reactions.

引用

页码：3057 / 3060

页数：4

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