Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic

被引：188

作者：

Williams, NA ^{[1
]}

Hirst, TR ^{[1
]}

Nashar, TO ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Bristol BS8 1TD, Avon, England

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0167-5699(98)01397-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cholera toxin and ifs close relative, Escherichia coli heat-labile enterotoxin, ave potent immunogens and mucosal adjuvents. The recent findings that their B subunits can promote tolerance highlights the complexity of their interactions with the immune system. Here, Neil Williams and colleagues review the mechanisms by which these molecules modulate leukocyte populations and seek to explain the paradox.

引用

页码：95 / 101

页数：7

共 64 条

[31]

Matousek MP, 1996, J IMMUNOL, V156, P4137

[32] IMMUNE-RESPONSE OF THE FEMALE RAT GENITAL-TRACT AFTER ORAL AND LOCAL IMMUNIZATION WITH KEYHOLE LIMPET HEMOCYANIN CONJUGATED TO THE CHOLERA TOXIN-B SUBUNIT [J].

MENGE, AC ;

MICHALEK, SM ;

RUSSELL, MW ;

MESTECKY, J .

INFECTION AND IMMUNITY, 1993, 61 (05) :2162-2171

[33] Structural studies of receptor binding by cholera toxin mutants [J].

Merritt, EA ;

Sarfaty, S ;

Jobling, MG ;

Chang, T ;

Holmes, RK ;

Hirst, TR ;

Hol, WGJ .

PROTEIN SCIENCE, 1997, 6 (07) :1516-1528

[34] STRUCTURE OF PARTIALLY-ACTIVATED ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN (LT) AT 2.6-ANGSTROM RESOLUTION [J].

MERRITT, EA ;

PRONK, SE ;

SIXMA, TK ;

KALK, KH ;

VANZANTEN, BAM ;

HOL, WGJ .

FEBS LETTERS, 1994, 337 (01) :88-92

[35] Cross-linking of cell surface ganglioside GM1 induces the selective apoptosis of mature CD8(+) T lymphocytes [J].

Nashar, TO ;

Williams, NA ;

Hirst, TR .

INTERNATIONAL IMMUNOLOGY, 1996, 8 (05) :731-736

[36] IMMUNOREGULATORY ROLE OF H-2 AND INTRA-H-2 ALLELES ON ANTIBODY-RESPONSES TO RECOMBINANT PREPARATIONS OF B-SUBUNITS OF ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN (RETXB) AND CHOLERA-TOXIN (RCTXB) [J].

NASHAR, TO ;

HIRST, TR .

VACCINE, 1995, 13 (09) :803-810

[37] Modulation of B-cell activation by the B subunit of Escherichia coli enterotoxin: receptor interaction up-regulates MHC class II, B7, CD40, CD25 and ICAM-1 [J].

Nashar, TO ;

Hirst, TR ;

Williams, NA .

IMMUNOLOGY, 1997, 91 (04) :572-578

[38] Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: Receptor binding is essential and induces differential modulation of lymphocyte subsets [J].

Nashar, TO ;

Webb, HM ;

Eaglestone, S ;

Williams, NA ;

Hirst, TR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :226-230

[39] Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages [J].

Norbury, CC ;

Hewlett, LJ ;

Prescott, AR ;

Shastri, N ;

Watts, C .

IMMUNITY, 1995, 3 (06) :783-791

[40] ADJUVANT EFFECT OF CHOLERA ENTEROTOXIN ON IMMUNE-RESPONSE OF MOUSE TO SHEEP RED BLOOD-CELLS [J].

NORTHRUP, RS ;

FAUCI, AS .

JOURNAL OF INFECTIOUS DISEASES, 1972, 125 (06) :672-&

← 1 2 3 4 5 6 7 →