Aging and Bone

被引：429

作者：

Boskey, A. L. ^{[1
]}

Coleman, R. ^{[1
]}

机构：

[1] Hosp Special Surg, New York, NY 10021 USA

来源：

JOURNAL OF DENTAL RESEARCH | 2010年 / 89卷 / 12期

关键词：

bone properties; aging; senescence; bone cells; bone mineral; review; AGE-RELATED-CHANGES; IDIOPATHIC JUVENILE OSTEOPOROSIS; FTIR MICROSPECTROSCOPIC ANALYSIS; COLLAGEN CROSS-LINKS; MINERAL DENSITY; CORTICAL BONE; ALVEOLAR BONE; TOOTH LOSS; MECHANICAL-PROPERTIES; GENE-EXPRESSION;

D O I：

10.1177/0022034510377791

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Bones provide mechanical and protective function, while also serving as housing for marrow and a site for regulation of calcium ion homeostasis. The properties of bones do not remain constant with age; rather, they change throughout life, in some cases improving in function, but in others, function deteriorates. Here we review the modifications in the mechanical function and shape of bones, the bone cells, the matrix they produce, and the mineral that is deposited on this matrix, while presenting recent theories about the factors leading to these changes.

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收藏

页码：1333 / 1348

页数：16

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