Regulation of intracellular HAP1 trafficking

被引：31

作者：

Rong, Juan ^{[1
]}

Li, Shi-Hua ^{[1
]}

Li, Xiao-Jiang ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2007年 / 85卷 / 14期

关键词：

huntingtin; polyglutamine; HAP1; trafficking; microtubule; phosphorylation;

D O I：

10.1002/jnr.21326

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A number of proteins are known to interact with huntingtin (htt), the Huntington's disease (HD) protein. Understanding the function of these htt-associated proteins could help elucidate the pathogenesis of HD and the role that htt plays in the disease process. The present review focuses on one such protein, huntingtin-associated protein 1 (HAP1), which has proved to be involved in intracellular trafficking. Unlike huntingtin, which is expressed ubiquitously throughout the brain and body, HAP1 is enriched in neurons, suggesting that its dysfunction could contribute to the selective neuropathology in HD. HAP1 binds microtubule-dependent transporters that engage anterograde or retrograde transport and also associates with a variety of organelles and membrane receptors. This raises the interesting issue of how the HAP1 trafficking function is regulated. We discuss recent evidence for the involvement of HAP1 in intracellular trafficking as well as potential mechanisms that may regulate its trafficking. (c) 2007 Wiley-Liss, Inc.

引用

页码：3025 / 3029

页数：5

共 59 条

[1] Huntington's disease of the endocrine pancreas: Insulin deficiency and diabetes mellitus due to impaired insulin gene expression [J].

Andreassen, OA ;

Dedeoglu, A ;

Stanojevic, V ;

Hughes, DB ;

Browne, SE ;

Leech, CA ;

Ferrante, RJ ;

Habener, JF ;

Beal, MF ;

Thomas, MK .

NEUROBIOLOGY OF DISEASE, 2002, 11 (03) :410-424

[2] Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation [J].

Bauer, A ;

Zilles, K ;

Matusch, A ;

Holzmann, C ;

Riess, O ;

von Hörsten, S .

JOURNAL OF NEUROCHEMISTRY, 2005, 94 (03) :639-650

[3] Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease [J].

Björkqvist, M ;

Petersén, Å ;

Bacos, K ;

Isaacs, J ;

Norlén, P ;

Gil, J ;

Popovic, N ;

Sundler, F ;

Bates, GP ;

Tabrizi, SJ ;

Brundin, P ;

Mulder, H .

HUMAN MOLECULAR GENETICS, 2006, 15 (10) :1713-1721

[4] The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient β-cell mass and exocytosis [J].

Björkqvist, M ;

Fex, M ;

Renström, E ;

Wierup, N ;

Petersén, Å ;

Gil, J ;

Bacos, K ;

Popovic, N ;

Li, JY ;

Sundler, F ;

Brundin, P ;

Mulder, H .

HUMAN MOLECULAR GENETICS, 2005, 14 (05) :565-574

[5] Fast transport and retrograde movement of huntingtin and HAP 1 in axons [J].

BlockGalarza, J ;

Chase, KO ;

Sapp, E ;

Vaughn, KT ;

Vallee, RB ;

DiFiglia, M ;

Aronin, N .

NEUROREPORT, 1997, 8 (9-10) :2247-2251

[6] Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior [J].

Chan, EYW ;

Nasir, J ;

Gutekunst, CA ;

Coleman, S ;

Maclean, A ;

Maas, A ;

Metzler, M ;

Gertsenstein, M ;

Ross, CA ;

Nagy, A ;

Hayden, MR .

HUMAN MOLECULAR GENETICS, 2002, 11 (08) :945-959

[7] Insulin and neurodegenerative disease: shared and specific mechanisms [J].

Craft, S ;

Watson, GS .

LANCET NEUROLOGY, 2004, 3 (03) :169-178

[8] Transcriptional repression of PGC-α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration [J].

Cui, Libin ;

Jeong, Hyunkyung ;

Borovecki, Fran ;

Parkhurst, Christopher N. ;

Tanese, Naoko ;

Krainc, Dimitri .

CELL, 2006, 127 (01) :59-69

[9] Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease [J].

Cummings, Damian M. ;

Milnerwood, Austen J. ;

Dallerac, Glenn M. ;

Waights, Verina ;

Brown, Jacki Y. ;

Vatsavayai, Sarat C. ;

Hirst, Mark C. ;

Murphy, Kerry P. S. J. .

HUMAN MOLECULAR GENETICS, 2006, 15 (19) :2856-2868

[10] Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism [J].

del Toro, Daniel ;

Canals, Josep M. ;

Gines, Silvia ;

Kojima, Masami ;

Egea, Gustavo ;

Alberch, Jordi .

JOURNAL OF NEUROSCIENCE, 2006, 26 (49) :12748-12757

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