Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning

被引:154
作者
Kleim, JA
Swain, RA
Armstrong, KA
Napper, RMA
Jones, TA
Greenough, WT
机构
[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA
[3] Univ Illinois, Dept Psychiat, Urbana, IL 61801 USA
[4] Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA
[5] Univ Illinois, Program Neurosci, Urbana, IL 61801 USA
[6] Univ Otago, Sch Med, Dept Anat, Dunedin, New Zealand
关键词
D O I
10.1006/nlme.1998.3827
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Complex motor skill learning, but not mere motor activity, leads to an increase in synapse number within the cerebellar cortex. The present experiment used quantitative electron microscopy to determine which synapse types were altered in number. Adult female rats were allocated to either an acrobatic condition (AC), a voluntary exercise condition (VX), or an inactive condition (IC). AC animals were trained to traverse an elevated obstacle course requiring substantial motor coordination to complete. VX animals were housed with unlimited access to running wheels and IC animals received no motor training but were handled briefly each day. Results showed the AC animals to have significantly more parallel fiber to Purkinje cell synapses than both the VX and IC animals. No other synapse type was significantly altered. Thus, the learning-dependent increase in synapse number observed within the cerebellar cortex is accomplished primarily through the addition of parallel fiber synapses. (C) 1998 Academic Press.
引用
收藏
页码:274 / 289
页数:16
相关论文
共 69 条
[11]   DIFFERENTIAL REARING ALTERS SPINE DENSITY ON MEDIUM-SIZED SPINY NEURONS IN THE RAT CORPUS STRIATUM - EVIDENCE FOR ASSOCIATION OF MORPHOLOGICAL PLASTICITY WITH EARLY RESPONSE GENE-EXPRESSION [J].
COMERY, TA ;
SHAH, R ;
GREENOUGH, WT .
NEUROBIOLOGY OF LEARNING AND MEMORY, 1995, 63 (03) :217-219
[12]   PAIRING OF PRESYNAPTIC AND POSTSYNAPTIC ACTIVITIES IN CEREBELLAR PURKINJE-CELLS INDUCES LONG-TERM CHANGES IN SYNAPTIC EFFICACY INVITRO [J].
CREPEL, F ;
JAILLARD, D .
JOURNAL OF PHYSIOLOGY-LONDON, 1991, 432 :123-141
[13]  
ECCLES JC, 1977, BRAIN RES, V127, P327, DOI 10.1016/0006-8993(77)90550-9
[14]  
Eccles JC, 1967, CEREBELLUM NEURONAL
[15]   LONG-TERM DEPRESSION OF PARALLEL FIBER SYNAPSES FOLLOWING STIMULATION OF CLIMBING FIBERS [J].
EKEROT, CF ;
KANO, M .
BRAIN RESEARCH, 1985, 342 (02) :357-360
[16]   CEREBELLAR PLASTICITY - MODIFICATION OF PURKINJE-CELL STRUCTURE BY DIFFERENTIAL REARING IN MONKEYS [J].
FLOETER, MK ;
GREENOUGH, WT .
SCIENCE, 1979, 206 (4415) :227-229
[17]   CEREBELLAR NEURONAL-ACTIVITY RELATED TO WHOLE-ARM REACHING MOVEMENTS IN THE MONKEY [J].
FORTIER, PA ;
KALASKA, JF ;
SMITH, AM .
JOURNAL OF NEUROPHYSIOLOGY, 1989, 62 (01) :198-211
[18]   CEREBELLAR CORTICAL ACTIVITY DURING ANTAGONIST COCONTRACTION AND RECIPROCAL INHIBITION OF FOREARM MUSCLES [J].
FRYSINGER, RC ;
BOURBONNAIS, D ;
KALASKA, JF ;
SMITH, AM .
JOURNAL OF NEUROPHYSIOLOGY, 1984, 51 (01) :32-49
[19]  
FUJITA M, 1982, BIOL CYBERN, V45, P195, DOI 10.1007/BF00336192
[20]   HOW CEREBELLUM COULD MEMORIZE MOVEMENTS [J].
GILBERT, P .
NATURE, 1975, 254 (5502) :688-689