Anti-allergic and anti-anaphylactic activity of picroliv -: A standardised iridoid glycoside fraction of Picrorhiza kurroa

被引：29

作者：

Baruah, CC ^{[1
]}

Gupta, PP ^{[1
]}

Nath, A ^{[1
]}

Patnaik, LGK ^{[1
]}

Dhawan, BN ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Pharmacol, ICMR, Ctr Adv Pharmacol Res Tradit Remedies, Lucknow 226001, Uttar Pradesh, India

来源：

PHARMACOLOGICAL RESEARCH | 1998年 / 38卷 / 06期

关键词：

picroliv; Picrorhiza kurroa; anti-allergic; anti-anaphylactic; Schultz-Dale;

D O I：

10.1006/phrs.1998.0397

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Picroliv, a standardised iridoid glycoside fraction from the root and rhizome of Picrorhiza kurroa at a dose of 25 mg kg(-1) p.o. inhibited passive cutaneous anaphylaxis in mice (82%) and rats (50-85%) and protected mast cells from degranulation (60-80%) in a concentration-dependant manner. Its effect was also studied in sensitised guinea pig ileum preparation in vitro (Schultz-Dale study) and in normal guinea pigs in vivo (Konzett-Rossler, in preparation). There was inhibition of the Schultz-Dale response in sensitised guinea pig ileum, but the bronchospasm induced by histamine could not be antagonised or prevented by Picroliv, indicating the absence of a direct post-synaptic histamine receptor blocking activity. (C) 1998 The Italian Pharmacological Society.

引用

页码：487 / 492

页数：6

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