MicroRNA roles in beta-catenin pathway

被引：105

作者：

Huang, Kai ^{[1
,2
,3
,4
]}

Zhang, Jun-Xia ^{[1
,2
,5
]}

Han, Lei ^{[1
,2
,3
,4
]}

You, Yong-Ping ^{[5
]}

Jiang, Tao ^{[6
]}

Pu, Pei-Yu ^{[1
,2
,3
,4
]}

Kang, Chun-Sheng ^{[1
,2
,3
,4
]}

机构：

[1] Tianjin Med Univ Gen Hosp, Dept Neurosurg, Tianjin 300052, Peoples R China

[2] Tianjin Neurol Inst, Lab Neurooncol, Tianjin 300052, Peoples R China

[3] Minist Educ, Key Lab Neurotrauma Variat & Regenerat, Tianjin 300052, Peoples R China

[4] Tianjin Municipal Govt, Tianjin 300052, Peoples R China

[5] Nanjing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Nanjing 210029, Peoples R China

[6] Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China

来源：

MOLECULAR CANCER | 2010年 / 9卷

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; ADENOMATOUS POLYPOSIS-COLI; GLYCOGEN-SYNTHASE KINASE-3; COLORECTAL-CANCER CELLS; GROWTH-FACTOR RECEPTOR; UP-REGULATES STAT3; SIGNALING PATHWAY; TUMOR-SUPPRESSOR; MIR-200; FAMILY; C-JUN;

D O I：

10.1186/1476-4598-9-252

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant beta-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to beta-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of beta-catenin targeted therapeutics for cancer treatment.

引用

页数：12

共 100 条

[1] e2f1 gene is a new member of Wnt/β-catenin/Tcf-regulated genes [J].

Abramova, Maria V. ;

Zatulovskiy, Evgeny A. ;

Svetlikova, Svetlana B. ;

Kukushkin, Alexander N. ;

Pospelov, Valery A. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (01) :142-146

[2] Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression [J].

Arce, Laura ;

Pate, Kira T. ;

Waterman, Marian L. .

BMC CANCER, 2009, 9

[3] R-Etodolac decreases β-catenin levels along with survival and proliferation of hepatoma cells [J].

Behari, Jaideep ;

Zeng, Gang ;

Otruba, Wade ;

Thompson, Michael D. ;

Muller, Peggy ;

Micsenyi, Amanda ;

Sekhon, Sandeep S. ;

Leoni, Lorenzo ;

Monga, Satdarshan P. S. .

JOURNAL OF HEPATOLOGY, 2007, 46 (05) :849-857

[4]

Belenkaya TY, 2002, DEVELOPMENT, V129, P4089

[5] β-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator [J].

Billin, AN ;

Thirlwell, H ;

Ayer, DE .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (18) :6882-6890

[6] The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136 [J].

Blume-Jensen, P ;

Janknecht, R ;

Hunter, T .

CURRENT BIOLOGY, 1998, 8 (13) :779-782

[7]

Brannon M, 1999, DEVELOPMENT, V126, P3159

[8] A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells [J].

Burk, Ulrike ;

Schubert, Joerg ;

Wellner, Ulrich ;

Schmalhofer, Otto ;

Vincan, Elizabeth ;

Spaderna, Simone ;

Brabletz, Thomas .

EMBO REPORTS, 2008, 9 (06) :582-589

[9] Wnt signaling: complexity at the surface [J].

Cadigan, KM ;

Liu, YI .

JOURNAL OF CELL SCIENCE, 2006, 119 (03) :395-402

[10] Nuclear GSK-3β inhibits the canonical Wnt signalling pathway in a β-catenin phosphorylation-independent manner [J].

Caspi, M. ;

Zilberberg, A. ;

Eldar-Finkelman, H. ;

Rosin-Arbesfeld, R. .

ONCOGENE, 2008, 27 (25) :3546-3555

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