Synthesis of cyclic peptides as mimics for the constrained conformation of structural analogues of HIV protease inhibitors

被引：27

作者：

Prabhakaran, EN ^{[1
]}

Rajesh, V ^{[1
]}

Dubey, S ^{[1
]}

Iqbal, J ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(00)01951-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A gamma -turn induced cyclisation of tripeptides 4 can be performed in a ring-closing metathesis reaction using Grubb's catalyst to the corresponding cyclic peptides 5. These cyclic peptides mimic the constrained conformation of structural analogues of potential HIV protease inhibitors. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：339 / 342

页数：4

共 17 条

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