The highly stereospecific enzyme catalysed transamination of 4-fluorophenylglyoxylic acid to 4-(S)-fluorophenylglycine

被引：11

作者：

Cameron, M

Cohen, D

Cottrell, IF

Kennedy, DJ

Roberge, C

Chartrain, M

机构：

[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

[2] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Dept Bioproc Res, Rahway, NJ 07065 USA

[3] Merck Sharp & Dohme Res Labs, Dept Proc Res, Hoddesdon EN11 9BU, Herts, England

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2001年 / 14卷 / 1-3期

关键词：

keto-acid; stereospecific; transaminase;

D O I：

10.1016/S1381-1177(00)00235-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell free extracts from a number of bacterial strains belonging to the Pseudomonas and Bacillus genera were found to catalyse the conversion of 4-fluorophenylglyoxylic acid to 4-(S)-fluorophenylglycine in high optical purity (99% ee). (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：1 / 5

页数：5

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