Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis

被引：21

作者：

Deng, YH

Jiang, TY

Sheng, SJ

Tianasoa-Ramamonjy, M

Snyder, JK

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

[2] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA

[3] ESSD Madagascar, Antananarivo, Madagascar

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 03期

关键词：

D O I：

10.1021/np9805140

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new 24,28-dinorolean-3-one derivatives, the remangilones A-C (1-3), were isolated from the dried leaves of Physena madagascariensis using a human mammary carcinoma cell line to guide the isolation. The structures of 1-3 were deduced primarily from NMR studies. Compounds 1 and 3, remangilones A and C, respectively, were found to be cytotoxic against two human breast cancer cell lines and induced apoptosis at concentrations of 2.3 mu M.

引用

页码：471 / 476

页数：6

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