Soluble polymer synthesis: An improved traceless linker methodology for aliphatic C-H bond formation

被引：43

作者：

Zhao, XY ^{[1
]}

Jung, KW ^{[1
]}

Janda, KD ^{[1
]}

机构：

[1] SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(96)02503-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A traceless linker was developed on a soluble polymer support. The methodology allows for the facile attachment of molecules possessing an alkyl halide appendage. The coupled molecule can be further functionalized before subsequent cleavage via a two-step oxidation-reduction sequence. This sequence allows for the synthesis of molecules containing no trace of the linker and the formation of a new C-H bond. (C) 1997, Elsevier Science Ltd.

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页码：977 / 980

页数：4

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