A linker that allows efficient formation of aliphatic C-H bonds on polymeric supports

Alkyl group bearing polymer 10 was prepared by way of sulfide 8 and thiol 11 in high yields. Cleavage of the alkyl chain from the PEG polymer support was accomplished either by homolysis under radical conditions or by desulfurization using Raney nickel to yield the new carbon-hydrogen bond product 12. The methodology developed will allow a variety of molecular scaffolds to be readily manipulated on a polymeric matrix. Copyright (C) 1996 Elsevier Science Ltd