Membrane fusion - SNAREs line up in new environment

被引：77

作者：

Jahn, R

Hanson, PI

机构：

[1] Max Planck Inst Biophys Chem, Dept Neurobiol, D-37077 Gottingen, Germany

[2] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

NATURE | 1998年 / 393卷 / 6680期

关键词：

D O I：

10.1038/29871

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fusion of intracellular membranes is essential to cellular processes ranging from growth to neuronal communication. But how does it occur? By reconstituting the proteins that are thought to be involved into artificial membranes, one group finds that three so-called SNARE proteins can form ternary complexes and induce interactions between lipid bilayers. These results are consistent with previous theories of how membrane fusion occurs, and they should allow other aspects of the process to be studied.

引用

页码：14 / 15

页数：2

共 15 条

[11] A PROTEIN ASSEMBLY-DISASSEMBLY PATHWAY IN-VITRO THAT MAY CORRESPOND TO SEQUENTIAL STEPS OF SYNAPTIC VESICLE DOCKING, ACTIVATION, AND FUSION [J].