Notch in fibrosis and as a target of anti-fibrotic therapy

被引：101

作者：

Hu, Biao ^{[1
]}

Phan, Sem H. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, 109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA

来源：

PHARMACOLOGICAL RESEARCH | 2016年 / 108卷

基金：

美国国家卫生研究院;

关键词：

Notch; Fibrosis; Myofibroblast; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATIC STELLATE CELLS; GAMMA-SECRETASE INHIBITOR; GROWTH-FACTOR-BETA; PULMONARY-FIBROSIS; SIGNALING PATHWAY; LIVER FIBROSIS; J-KAPPA; SYSTEMIC-SCLEROSIS; CARDIAC FIBROSIS;

D O I：

10.1016/j.phrs.2016.04.010

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseases in diverse organs and tissues. Different effects of Notch activation are observed depending on cellular and tissue context as well as in both physiologic and pathologic states. Close interactions of Notch signaling pathway with other signaling pathways have been identified. In this review, current knowledge on the role of the Notch signaling with special focus on fibrosis and its potential as a therapeutic target is summarized. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：57 / 64

页数：8

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