Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes

被引：64

作者：

Haraguchi, H ^{[1
]}

Ohmi, I ^{[1
]}

Sakai, S ^{[1
]}

Fukuda, A ^{[1
]}

Toihara, Y ^{[1
]}

Fujimoto, T ^{[1
]}

Okamura, N ^{[1
]}

Yagi, A ^{[1
]}

机构：

[1] FUKUYAMA UNIV,FAC PHARM & PHARMACEUT SCI,FUKUYAMA,HIROSHIMA 72902,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 04期

关键词：

D O I：

10.1021/np9601622

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The sulfated flavonoids in Polygonum hydropiper showed potent inhibiton against lens aldose reductase. Among these flavonoids isorhamnetin 3,7-disulfate (5) was most potent. Kinetic analysis showed that 5 exhibited noncompetitive inhibition against both dl-glyceraldehyde and NADPH.

引用

页码：443 / 445

页数：3

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