Application of the sulfonamide functional group as an anchor for solid phase organic synthesis (SPOS)

被引：55

作者：

Beaver, KA ^{[1
]}

Siegmund, AC ^{[1
]}

Spear, KL ^{[1
]}

机构：

[1] CHIRON CORP,EMERYVILLE,CA 94608

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 08期

关键词：

D O I：

10.1016/0040-4039(95)02418-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sulfonyl chlorides have been found to readily couple to an amino functionalized resin. The resulting sulfonamide anchoring group is stable to a variety of reactions commonly used in SPOS. Acid induced cleavage is facile, affording functionalized sulfonamides in high yields.

引用

页码：1145 / 1148

页数：4

共 10 条

[1]

DANKWARDT SM, 1995, TETRAHEDRON LETT, V36, P4923, DOI 10.1016/0040-4039(95)00930-B

[2] FORMATION OF CARBON-CARBON BOND ON SOLID SUPPORT - APPLICATION OF THE STILLE REACTION [J].