Nuclear and mitochondrial DNA repair: similar pathways?

被引：239

作者：

Larsen, NB ^{[1
]}

Rasmussen, M ^{[1
]}

Rasmussen, LJ ^{[1
]}

机构：

[1] Roskilde Univ, Dept Chem & Life Sci, DK-4000 Roskilde, Denmark

来源：

MITOCHONDRION | 2005年 / 5卷 / 02期

关键词：

DNA repair; mitochondria;

D O I：

10.1016/j.mito.2005.02.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial DNA (mtDNA) alterations are implicated in a broad range of human diseases and alterations of the mitochondrial genome are assumed to be a result of its high susceptibility to oxidative damage and its limited DNA repair compared to nuclear DNA (nDNA). Characterization of DNA repair mechanisms has generally focused on these processes in nDNA but increasing interest and research effort have contributed to our knowledge of the mechanisms underlying DNA repair in mitochondria. In this review, we make comparisons between nDNA and mtDNA repair pathways and propose a model for how these pathways interact in mitochondria. (c) 2005 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：89 / 108

页数：20

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