Recombinant human erythropoietin stimulates vasculogenesis and wound healing in a patient with systemic sclerosis complicated by severe skin ulcers

被引：13

作者：

Ferri, C. ^{[1
]}

Giuggioli, D. ^{[1
]}

Manfredi, A. ^{[1
]}

Quirici, N. ^{[2
]}

Scavullo, C. ^{[2
]}

Colaci, M. ^{[1
]}

Gianelli, U. ^{[3
]}

Deliliers, G. Lambertenghi ^{[4
]}

Del Papa, N. ^{[5
]}

机构：

[1] Univ Modena & Reggio Emilia, Rheumatol Unit, Dept Internal Med, Policlin Modena, I-41100 Modena, Italy

[2] Univ Milan, Matarelli Fdn, Dept Phamacol Chemotherapy & Med Toxicol, Milan, Italy

[3] Hosp S Paolo, Chair Pathol Anat 2, Milan, Italy

[4] Fondaz Osped Maggiore Policlin, Bone Marrow Transplant Ctr, Haematol Operating Unit, Milan, Italy

[5] G Pini Hosp, Milan, Italy

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2010年 / 35卷 / 08期

关键词：

BONE-MARROW;

D O I：

10.1111/j.1365-2230.2010.03847.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Systemic sclerosis (SSc) is often complicated by severe skin ulcers that are unresponsive to traditional treatments. Vascular alterations are responsible for the ischaemic features of the disease in both the skin and visceral organs. Defective neoangiogenesis correlates with an abnormally reduced quantity of circulating endothelial progenitor cells (EPCs) caused by impaired maturation potential and proliferative capacity of bone-marrow endothelial stem cells. We report a patient with nonhealing cutaneous ulcers successfully treated with recombinant human erythropoietin (rHuEPO). The possible biological effects of this drug were also investigated. Before rHuEPO treatment, the bone-marrow sample contained reduced numbers of EPCs, which were functionally impaired. After a 6-month rHuEPO cycle, a marked increase in endothelial progenitor markers was seen, along with a significant reduction in their apoptotic rates. The clinical and laboratory data variations before and after rHuEPO treatment give new insights into the pathogenetic role of impaired endothelial stem-cell maturation and defective neoangiogenesis in patients with SSc.

引用

页码：885 / 887

页数：3

共 10 条

[1]

The non-haematopoietic biological effects of erythropoietin [J].