Delirium in the non-demented oldest old in the general population:: risk factors and prognosis

被引:64
作者
Rahkonen, T
Eloniemi-Sulkava, U
Halonen, P
Verkkoniemi, A
Niinistö, L
Notkola, IL
Sulkava, R
机构
[1] Univ Kuopio, Dept Publ Hlth & Gen Practice, Div Geriatr, FIN-70211 Kuopio, Finland
[2] Univ Kuopio, Ctr Comp, FIN-70211 Kuopio, Finland
[3] Univ Helsinki, Dept Neurol, FIN-00290 Helsinki, Finland
[4] Katriina Geriatr Hosp, Vantaa, Finland
[5] Kuopio Univ Hosp, SF-70210 Kuopio, Finland
关键词
delirium; oldest old; risk factors; prognosis; dementia; general population;
D O I
10.1002/gps.356
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background The oldest old are prone to develop delirium. Studies into risk factors for delirium have been carried out predominantly in younger age groups. The aim of this population-based follow-up study was to investigate the risk factors for delirium requiring medical attention and subsequent prognosis in the non-demented general population aged greater than or equal to 85 years. Method The study included the non-demented subjects in the population-based Vantaa 85 + study. After the 3-year observation period, 199 subjects (91% of those surviving) were re-examined and their medical records were evaluated for episodes of delirium. The subjects were followed up with respect to mortality for another 2 years. Results During the 3-year observational period, 20 subjects (10%) had been diagnosed as having had an episode of delirium. A Mini-Mental State Examination score of < 24 (odds ratio (OR) 3.44, confidence interval (CI=95%) 1.27-9.32) and high systolic blood pressure (OR 3.08, CI 1.08-8.79) were identified as independent risk factors for delirium. The association between the delirium episode and a new diagnosis of dementia was significant (p=0.001). The mortality rate was greater among those subjects who experienced delirium than among subjects without this syndrome (p = 0.008). Conclusions Mild cognitive impairment and high systolic blood pressure were found to be risk factors for delirium requiring medical attention in the general non-demented population aged greater than or equal to 85 years. The study also highlights the significant association between delirium and a new dementia diagnosis in this age group. Copyright (C) 2001 John Wiley & Sons. Ltd.
引用
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页码:415 / 421
页数:7
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