Unification of protein families

被引：42

作者：

Holm, L ^{[1
]}

机构：

[1] European Mol Biol Lab, European Bioinformat Inst, Cambridge CB10 1SD, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(98)80072-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Computational biology exploits the evolutionary connectivity between proteins and protein families to predict structural and functional properties of uncharacterized gene products. In the past year, conceptual and statistical refinements have substantially improved algorithms for the detection of remote homologues. In conjunction with the rapid growth of biological databases, the global organization of proteins into sequence families, functional families and structural families has become both pertinent and feasible.

引用

页码：372 / 379

页数：8

共 73 条

[1] Do aligned sequences share the same fold? [J].

Abagyan, RA ;

Batalov, S .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 273 (01) :355-368

[2] AMINO-ACID SUBSTITUTION MATRICES FROM AN INFORMATION THEORETIC PERSPECTIVE [J].

ALTSCHUL, SF .

JOURNAL OF MOLECULAR BIOLOGY, 1991, 219 (03) :555-565

[3] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[4] Structure of the chromatin binding (chromo) domain from mouse modifier protein 1 [J].

Ball, LJ ;

Murzina, NV ;

Broadhurst, RW ;

Raine, ARC ;

Archer, SJ ;

Stott, FJ ;

Murzin, AG ;

Singh, PB ;

Domaille, PJ ;

Laue, ED .

EMBO JOURNAL, 1997, 16 (09) :2473-2481

[5] A P-LOOP-LIKE MOTH IN A WIDESPREAD ATP PYROPHOSPHATASE DOMAIN - IMPLICATIONS FOR THE EVOLUTION OF SEQUENCE MOTIFS AND ENZYME-ACTIVITY [J].

BORK, P ;

KOONIN, EV .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 1994, 20 (04) :347-355

[6] GENE DUPLICATIONS IN HAEMOPHILUS-INFLUENZAE [J].

BRENNER, SE ;

HUBBARD, T ;

MURZIN, A ;

CHOTHIA, C .

NATURE, 1995, 378 (6553) :140-140

[7] A flexible motif search technique based on generalized profiles [J].

Bucher, P ;

Karplus, K ;

Moeri, N ;

Hofmann, K .

COMPUTERS & CHEMISTRY, 1996, 20 (01) :3-23

[8] The solution structure of the S1 RNA binding domain: A member of an ancient nucleic acid-binding fold [J].

Bycroft, M ;

Hubbard, TJP ;

Proctor, M ;

Freund, SMV ;

Murzin, AG .

CELL, 1997, 88 (02) :235-242

[9] Crystal structure of human glyoxalase .1. Evidence for gene duplication and 3D domain swapping [J].

Cameron, AD ;

Olin, B ;

Ridderstrom, M ;

Mannervik, B ;

Jones, TA .

EMBO JOURNAL, 1997, 16 (12) :3386-3395

[10] DNA shuffling of a family of genes from diverse species accelerates directed evolution [J].

Crameri, A ;

Raillard, SA ;

Bermudez, E ;

Stemmer, WPC .

NATURE, 1998, 391 (6664) :288-291

← 1 2 3 4 5 6 7 8 →