Unification of protein families

被引：42

作者：

Holm, L ^{[1
]}

机构：

[1] European Mol Biol Lab, European Bioinformat Inst, Cambridge CB10 1SD, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(98)80072-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Computational biology exploits the evolutionary connectivity between proteins and protein families to predict structural and functional properties of uncharacterized gene products. In the past year, conceptual and statistical refinements have substantially improved algorithms for the detection of remote homologues. In conjunction with the rapid growth of biological databases, the global organization of proteins into sequence families, functional families and structural families has become both pertinent and feasible.

引用

页码：372 / 379

页数：8