Trace analysis of the antineoplastics ifosfamide and cyclophosphamide in sewage water by two-step solid-phase extraction and gas chromatography mass spectrometry

被引：118

作者：

StegerHartmann, T ^{[1
]}

Kummerer, K ^{[1
]}

Schecker, J ^{[1
]}

机构：

[1] INST ENVIRONM MED & HOSP EPIDEMIOL,D-79106 FREIBURG,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 726卷 / 1-2期

关键词：

solid-phase extraction; waste water; ifosfamide; cyclophosphamide;

D O I：

10.1016/0021-9673(95)01063-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A sensitive, specific and highly reproducible method for the analysis of the two antineoplastics, ifosfamide and cyclophosphamide, in sewage water at the ppt-level is presented. The method includes a two-step solid-phase extraction (SPE) on C-18 and SiOH material and GC-MS analysis using single ion monitoring (SIM). The method was applied to degradational studies of the two drugs in laboratory-scale sewage treatment plants (LSSTPs) and to quantification in hospital sewage water samples. It was shown that the drugs were not degraded in LSSTPs and that they turned up in hospital sewage water.

引用

页码：179 / 184

页数：6

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