ICV administration of CRF blocker (CRF9-41 δ helical) reduces morphine withdrawal in rats

1. The effects of CRF9-41 partial derivative helical on morphine withdrawal signs in rats were studied 2. Intracerebroventricular administration of CRF9-41 partial derivative helical 5 at 10 mu g/kg reduced central and peripheral symptons of the withdrawal syndrome, such as ptosis, jumping, wet dog shakes and teeth chatering; other signs remained unchanged. The effect were not dose dependent. 3. The hypothermi characteristic of the Withdrawal sindrome was reduced by CRF9-41 partial derivative helical. 4. These results suggest that the hypothalamo pituitary adrenal(HPA) axis play an important role in the morphine withdrawal syndrome in rats.