ICV administration of CRF blocker (CRF9-41 δ helical) reduces morphine withdrawal in rats

被引：13

作者：

Brugger, S

Sanchez, R

Brugger, AJ

Martinez, JA ^{[1
]}

机构：

[1] Univ Murcia, Sch Med, Pharmacol Unit, Dept Physiol & Pharmacol, Murcia 30700, Spain

[2] Gen Hosp, Dept Psychiat, Albacete, Spain

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1998年 / 22卷 / 05期

关键词：

CRF9-41 delta helical antagonist; hypothalamo - pituitary-adrenal axis; morphine withdrawal syndrome; opoid;

D O I：

10.1016/S0278-5846(98)00039-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. The effects of CRF9-41 partial derivative helical on morphine withdrawal signs in rats were studied 2. Intracerebroventricular administration of CRF9-41 partial derivative helical 5 at 10 mu g/kg reduced central and peripheral symptons of the withdrawal syndrome, such as ptosis, jumping, wet dog shakes and teeth chatering; other signs remained unchanged. The effect were not dose dependent. 3. The hypothermi characteristic of the Withdrawal sindrome was reduced by CRF9-41 partial derivative helical. 4. These results suggest that the hypothalamo pituitary adrenal(HPA) axis play an important role in the morphine withdrawal syndrome in rats.

引用

页码：775 / 785

页数：11

共 26 条

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