Understanding the odd science of aging

被引：1296

作者：

Kirkwood, TBL ^{[1
]}

机构：

[1] Newcastle Univ, Inst Ageing & Hlth, Henry Wellcome Lab Biogerontol Res, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

来源：

CELL | 2005年 / 120卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.cell.2005.01.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evolutionary considerations suggest aging is caused not by active gene programming but by evolved limitations in somatic maintenance, resulting in a build-up of damage. Ecological factors such as hazard rates and food availability influence the trade-offs between investing in growth, reproduction, and somatic survival, explaining why species evolved different life spans and why aging rate can sometimes be altered, for example, by dietary restriction. To understand the cell and molecular basis of aging is to unravel the multiplicity of mechanisms causing damage to accumulate and the complex array of systems working to keep damage at bay.

引用

页码：437 / 447

页数：11

共 80 条

[1] Evolutionary biology - Mortality and lifespan [J].