Increased expression of the TIAR protein in the hippocampus of Alzheimer patients

被引：9

作者：

Oleana, VH ^{[1
]}

Salehi, A ^{[1
]}

Swaab, DF ^{[1
]}

机构：

[1] Netherlands Inst Brain Res, Grad Sch Neurosci Amsterdam, NL-1105 AZ Amsterdam, Netherlands

来源：

NEUROREPORT | 1998年 / 9卷 / 07期

关键词：

Alzheimer's disease; apoptosis; hippocampus; human; immunocytochemistry; TIAR;

D O I：

10.1097/00001756-199805110-00037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

T-CELL restricted intracellular antigen related protein (TIAR) is an RNA-binding protein that is supposed to be involved in the process of stress-induced apoptosis. TIAR triggers DNA fragmentation in permeabilized thymocytes and its expression diminishes in the cell nucleus and rises simultaneously in the cytoplasm during Fas-induced cell death. Using a monoclonal antibody against TIAR, we stained different areas of the hippocampus from seven controls and 14 patients with Alzheimer's disease (AD). There was a clear expression of TIAR in the hippocampus of non-demented controls. Surprisingly, a significant increase was found in the expression of TIAR in the hippocampal area in AD. The increased expression of TIAR in AD may be related to the process of neurodegeneration in the hippocampus. (C) 1998 Rapid Science Ltd.

引用

页码：1451 / 1454

页数：4

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