The pineal gland is not essential for circadian expression of rat period homologue (rper2) mRNA in the suprachiasmatic nucleus and peripheral tissues

被引：16

作者：

Oishi, K

Murai, I

Sakamoto, K

Otsuka, H

Miyake, Y

Nagase, T

Ishida, N

机构：

[1] MITI, Agcy Ind Sci & Technol, Natl Inst Biosci & Human Technol, Ishida Grp Clock Gene, Tsukuba, Ibaraki 3058566, Japan

[2] Nihon Univ, Sch Med, Dept Biochem, Tokyo 1730032, Japan

[3] Nihon Univ, Sch Med, Dept Obstet & Gynecol, Tokyo 1790072, Japan

[4] Kazusa DNA Res Inst, Chiba 2920812, Japan

[5] Tokyo Inst Technol, Dept Biomol Engn, Kanagawa 2268501, Japan

来源：

BRAIN RESEARCH | 2000年 / 885卷 / 02期

关键词：

circadian rhythm; period homologue; pinealectomy; melatonin; suprachiasmatic nucleus; peripheral tissues;

D O I：

10.1016/S0006-8993(00)02982-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the functional involvement of the pineal gland in circadian expression of the rat period homolog gene (rPer2) in the suprachiasmatic nucleus (SCN) and peripheral tissues, we performed Northern blot analysis in tissues from pinealectomized rats. The ectomy did not have any significant effects on rPer2 mRNA expression patterns both in a daily light-dark condition and in a constant darkness. These results suggest that the rhythmic secretion of pineal melatonin is not essential for the circadian expression of clock genes in the SCN and other peripheral tissues of rats. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：298 / 302

页数：5

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