Clinical Significance of Microbial Infection and Adaptation in Cystic Fibrosis

被引:297
作者
Hauser, Alan R. [1 ,2 ]
Jain, Manu [3 ]
Bar-Meir, Maskit [4 ]
McColley, Susanna A. [4 ]
机构
[1] Northwestern Univ, Dept Microbiol Immunol, Feinberg Sch Med, Chicago, IL 60611 USA
[2] Northwestern Univ, Div Infect Dis, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
[3] Northwestern Univ, Div Pulm & Crit Care Med, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
[4] Northwestern Univ, Div Pulm Med, Feinberg Sch Med, Dept Pediat, Chicago, IL 60611 USA
基金
美国国家卫生研究院;
关键词
ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; BURKHOLDERIA-CEPACIA-COMPLEX; RESISTANT STAPHYLOCOCCUS-AUREUS; SMALL-COLONY VARIANTS; PSEUDOMONAS-AERUGINOSA INFECTION; RESPIRATORY VIRAL-INFECTIONS; AIRWAY EPITHELIAL-CELLS; CHRONIC LUNG INFECTION; III SECRETION SYSTEM; ACHROMOBACTER ALCALIGENES XYLOSOXIDANS;
D O I
10.1128/CMR.00036-10
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A select group of microorganisms inhabit the airways of individuals with cystic fibrosis. Once established within the pulmonary environment in these patients, many of these microbes adapt by altering aspects of their structure and physiology. Some of these microbes and adaptations are associated with more rapid deterioration in lung function and overall clinical status, whereas others appear to have little effect. Here we review current evidence supporting or refuting a role for the different microbes and their adaptations in contributing to poor clinical outcomes in cystic fibrosis.
引用
收藏
页码:29 / 70
页数:42
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