Enantioselective synthesis of β-hydroxy acid derivatives via a one-pot aldol reaction-dynamic kinetic resolution

被引：82

作者：

Huerta, FF ^{[1
]}

Bäckvall, JE ^{[1
]}

机构：

[1] Univ Stockholm, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 08期

关键词：

D O I：

10.1021/ol015682p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Combining dynamic kinetic resolution with an aldol reaction provides access to P-hydroxy ester derivatives with high enantiomeric purity (up to 99% ee) in a one-pot procedure, Only simple starting materials are required in this enantioselective process, and preformation of a silyl enol ether is not necessary.

引用

页码：1209 / 1212

页数：4

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