Cerebrospinal fluid production is normal in Down syndrome

被引：9

作者：

Atack, JR

Rapoport, SI

Schapiro, MB

机构：

[1] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England

[2] NIA, Neurosci Lab, NIH, Bethesda, MD 20892 USA

来源：

NEUROBIOLOGY OF AGING | 1998年 / 19卷 / 04期

关键词：

cerebrospinal fluid; Down syndrome; protein; caudorostral gradient;

D O I：

10.1016/S0197-4580(98)00069-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The rate of production of cerebrospinal fluid (CSF) and the caudorostral gradients of total CSF protein were measured in seven subjects with Down syndrome (DS) and compared to age-matched healthy normal volunteers. The CSF production rate in DS subjects (0.35 +/- 0.02 mL/min.) did not differ significantly from normal subjects (0.37 +/- 0.09 mL/min.). In addition, the caudorostral gradient of total protein was similar in DS and normal subjects, with more caudal fractions of lumbar CSF having higher total protein levels than more rostral fractions. These data suggest that there is no gross distrubance in CSF dynamics in DS. (C) 1998 Elsevier Science Inc.

引用

页码：307 / 309

页数：3

共 15 条

[1] CEREBROSPINAL-FLUID GRADIENTS OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE ACTIVITY IN HEALTHY AGING [J].