Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy

被引：1864

作者：

Robinson, Joshua T. ^{[1
]}

Tabakman, Scott M. ^{[1
]}

Liang, Yongye ^{[1
]}

Wang, Hailiang ^{[1
]}

Casalongue, Hernan Sanchez ^{[1
]}

Daniel Vinh ^{[1
]}

Dai, Hongjie ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 17期

关键词：

CARBON NANOTUBES; DRUG-DELIVERY; SHEETS; MICE; REDUCTION; HYBRID; AGENTS; SIZE;

D O I：

10.1021/ja2010175

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We developed nanosized, reduced graphene oxide (nano-rGO) sheets with high near-infrared (NIR) light absorbance and biocompatibility for potential photothermal therapy. The single-layered nano-rGO sheets were similar to 20 nm in average lateral dimension, functionalized noncovalently by amphiphilic PEGylated polymer chains to render stability in biological solutions and exhibited 6-fold higher NIR absorption than nonreduced, covalently PEGylated nano-GO. Attaching a targeting peptide bearing the Arg-Gly-Asp (RGD) motif to nano-rGO afforded selective cellular uptake in U87MG cancer cells and highly effective photoablation of cells in vitro. In the absence of any NIR irradiation, nano-rGO exhibited little toxicity in vitro at concentrations well above the doses needed for photothermal heating. This work established nano-rGO as a novel photothermal agent due to its small size, high photothermal efficiency, and low cost as compared to other NIR photothermal agents including gold nanomaterials and carbon nanotubes.

引用

收藏

页码：6825 / 6831

页数：7

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