Does a stretched DNA structure dictate the helical geometry of RecA-like filaments?

被引：39

作者：

Egelman, EH ^{[1
]}

机构：

[1] Univ Virginia, Hlth Sci Ctr, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2001年 / 309卷 / 03期

关键词：

DNA; RecA; recombination;

D O I：

10.1006/jmbi.2001.4686

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins in the RecA/Rad51/RadA/UvsX family form helical filaments on DNA in which the DNA is stretched and untwisted. A comparison of the average helical parameters of these filaments from five different proteins, obtained from archaea, eubacteria and eukaryotes, suggests that an intrinsic state of DNA may be responsible for the conservation of these particular filament forms across evolution. Ln this view, these proteins stabilize this existing state of DNA, rather than induce a novel conformation. (C) 2001 Academic Press.

引用

页码：539 / 542

页数：4

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