Effects of hemodialysis on circulating adrenomedullin concentrations in patients with end-stage renal disease

被引：18

作者：

Toepfer, M

Schlosshauer, M

Sitter, T

Burchardi, C

Behr, T

Schiffl, H

机构：

[1] Univ Munich, Med Klin, Klinikum Innenstadt, Dept Nephrol, D-80336 Munich, Germany

[2] Univ Munich, Med Klin, Klinikum Innenstadt, Dept Clin Pharmacol, D-80336 Munich, Germany

[3] Univ Munich, Med Klin, Klinikum Innenstadt, Dept Cardiol, D-80336 Munich, Germany

来源：

BLOOD PURIFICATION | 1998年 / 16卷 / 05期

关键词：

adrenomedullin; end-stage renal disease; hemodialysis;

D O I：

10.1159/000014344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To characterize the determinants of circulating levels of adrenomedullin (AM), the plasma levels of this peptide were measured in 58 patients with end-stage renal disease on hemodialysis, Predialysis plasma levels of AM were more than twice as high in patients on hemodialysis as compared to controls. In hemodialysis patients with heart failure (NYHA classes II-IV) or hypertensive HD patients plasma levels of AM were significantly higher than in patients with end-stage renal disease only. Plasma levels of AM were clot altered immediately by hemodialysis but decreased significantly 14-20 h after hemodialysis, AM plasma levels before hemodialysis and 14-20 h after hemodialysis were correlated with the corresponding mean arterial pressure.

引用

页码：269 / 274

页数：6

共 16 条

[1] Elevated plasma levels of human adrenomedullin in cardiovascular, respiratory, hepatic and renal disorders [J].