Repetitive transcranial magnetic stimulation in the treatment of depression in adolescents: An open-label study

被引：66

作者：

Bloch, Yarval ^{[1
]}

Grisaru, Nimrod ^{[2
]}

Harel, Eiran V. ^{[1
]}

Beitler, Gabriela ^{[1
]}

Faivel, Nurit ^{[1
]}

Ratzoni, Gideon ^{[1
]}

Stein, Daniel ^{[3
]}

Levkovitz, Yechiel ^{[1
]}

机构：

[1] Shalvata Mental Hlth Ctr, Hod Hasharon, Israel

[2] Ben Gurion Univ Negev, Fac Hlth Sci, Minist Hlth, Mental Hlth Ctr, Beer Sheva, Israel

[3] Safra Childrens Hosp, Chaim Sheba Med Ctr, Pediat Psychosomat Dept, Tel Hashomer, Israel

来源：

JOURNAL OF ECT | 2008年 / 24卷 / 02期

关键词：

adolescents; depression; transcranial magnetic stimulation;

D O I：

10.1097/YCT.0b013e318156aa49

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Objective: This open-label pilot study examined repetitive transcranial magnetic stimulation as a possible treatment of adolescent resistant depression. Method: Nine adolescents (aged 16-18 years) with severe resistant depression (determined by SCID) were recruited, and their depression, suicidality, and cognitive functions were evaluated before, during, and after a course of twenty 10-Hz, 2-second trains (intertrain intervals of 58 seconds) given over 20 min/d over 14 working days. Results: Lower levels of depression with progression in therapy were recorded by both the Beck Depression Inventory and Child Depression Rating Scale measures (F-1.7,F-14.01 = 4.52, P < 0.05; F-4,F-32 = 6.645, P < 0.01, respectively). Three patients reached the primary outcome measure of less than 30% reduction in their Child Depression Rating Scale. The effect on suicidality was not significant. Side effects were considered mild. Conclusions: Repetitive transcranial magnetic stimulation might be a possible therapy for adolescent depression. Our preliminary findings warrant double-blind, controlled studies.

引用

页码：156 / 159

页数：4