Structure-based systems biology: a zoom lens for the cell

被引：21

作者：

Aloy, P ^{[1
]}

Russell, RB ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

FEBS LETTERS | 2005年 / 579卷 / 08期

关键词：

systems biology; three-dimensional structure; protein interaction network; protein complex;

D O I：

10.1016/j.febslet.2005.02.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types of information. Here, we discuss how the incorporation of high-resolution structural data can provide key molecular details often necessary to understand the complex connection between individual molecules and cell behavior. We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the interfaces of interacting proteins. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：1854 / 1858

页数：5

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