A method for generating nitrile oxides from nitroalkanes: a microwave assisted route for isoxazoles

被引：46

作者：

Giacomelli, G ^{[1
]}

De Luca, L ^{[1
]}

Porcheddu, A ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

TETRAHEDRON | 2003年 / 59卷 / 29期

关键词：

isoxazoline; solid-phase synthesis; microwave condition; ALPHA-AMINO-ACIDS; EFFICIENT; ALDOXIMES; CHLORIDE; ALCOHOLS; ESTERS;

D O I：

10.1016/S0040-4020(03)00859-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient route has been developed for generation of nitrile oxides in situ from nitroalkanes under very mild conditions using microwave irradiation, using 4-(4,6-dimethoxy[1,3,5]triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) and DMAP as catalyst. Isoxazolines and isoxazoles are obtained in very good yields compared to known methods. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：5437 / 5440

页数：4

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