Fragile X:: Translation in action

被引：84

作者：

Bear, Mark F. ^{[1
]}

Dolen, Gul ^{[1
]}

Osterweil, Emily ^{[1
]}

Nagarajan, Naveen ^{[1
]}

机构：

[1] MIT, Howard Hughes Med Inst, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

来源：

NEUROPSYCHOPHARMACOLOGY | 2008年 / 33卷 / 01期

关键词：

autism; fragile x; metabotropic glutamate receptor; cerebral protein synthesis; synaptic plasticity; developmental disorder;

D O I：

10.1038/sj.npp.1301610

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fragile X is a synapsopathy-a disorder of synaptic function and plasticity. Recent studies using mouse models of the disease suggest that the critical defect is altered regulation of synaptic protein synthesis. Various strategies to restore balanced synaptic protein synthesis have been remarkably successful in correcting widely varied mutant phenotypes in mice. Insights gained by the study of synaptic plasticity in animal models of fragile X have suggested novel therapeutic approaches, not only for human fragile X but also for autism and mental retardation of unknown etiology.

引用

页码：84 / 87

页数：4

共 28 条

[1] The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain [J].