Brain microbleeds and Alzheimer's disease: innocent observation or key player?

被引：236

作者：

Cordonnier, Charlotte ^{[1
]}

van der Flier, Wiesje M. ^{[2
,3
,4
]}

机构：

[1] Univ Lille Nord France, CHU Lille, EA 1046, F-59000 Lille, France

[2] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands

来源：

BRAIN | 2011年 / 134卷

关键词：

brain microbleeds; Alzheimer's disease; dementia; CEREBRAL AMYLOID ANGIOPATHY; APOLIPOPROTEIN-E EPSILON-4; SMALL-VESSEL DISEASE; COGNITIVE FUNCTION; INTRACEREBRAL HEMORRHAGE; SUPERFICIAL SIDEROSIS; SENILE PLAQUES; RISK-FACTORS; BIOMARKERS; PREVALENCE;

D O I：

10.1093/brain/awq321

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain microbleeds are small dot-like lesions appearing as hyposignals on gradient echo magnetic resonance sequences. In Alzheimer's disease, brain microbleeds are of special interest as they may play a crucial role in the pathophysiology. They may be a missing link between two important theories on the neuropathogenesis of Alzheimer's disease-the amyloid cascade hypothesis and the vascular hypothesis. Moreover, they may affect the clinical course of the disease and may have therapeutic consequences. The aim of this article is to review available data to understand the meaning of brain microbleeds in clinical terms and underlying pathology in the context of Alzheimer's disease. We also review the available evidence and highlight the pitfalls of our current knowledge on brain microbleeds in the setting of clinical trials design.

引用

页码：335 / 344

页数：10

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