Use of Yokukansan (TJ-54) in the Treatment of Neurological Disorders: A Review

被引：33

作者：

de Caires, S. ^{[1
]}

Steenkamp, V. ^{[1
]}

机构：

[1] Univ Pretoria, Fac Hlth Sci, Dept Pharmacol, Sch Med, ZA-0001 Pretoria, South Africa

来源：

PHYTOTHERAPY RESEARCH | 2010年 / 24卷 / 09期

关键词：

Alzheimer's disease; dementia; herbal remedy; Kampo; TJ-54; Yokukansan; TRADITIONAL JAPANESE MEDICINE; LONG-TERM POTENTIATION; METHYL-D-ASPARTATE; PORIA-COCOS WOLF; YI-GAN-SAN; PSYCHOLOGICAL SYMPTOMS; UNCARIA-RHYNCHOPHYLLA; PSYCHIATRIC-SYMPTOMS; LEARNING DEFICIT; TRANSGENIC MICE;

D O I：

10.1002/ptr.3146

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Kampo herbal remedies are reported to have a wide range of indications and have attracted attention due to reports suggesting that these remedies are effective when used in disease treatment while maintaining a favourable quality of life. Yokukansan, also known as TJ-54, is composed of seven herbs; Angelica acutiloba, Atractylodes lancea, Bupleurum falcatum, Poria cocos, Glycyrrhiza uralensis, Cnidium officinale and Uncaria rhynchophylla. Yokukansan is used to treat insomnia and irritability as well as screaming attacks, sleep tremors and hypnic myoclonia, and neurological disorders which include dementia and Alzheimer's disease - the focus of this article. It is concluded that Yokukansan is a versatile herbal remedy with a variety of effects on various neurological states, without reported adverse effects. Traditional herbal medicines consist of a combination of constituents which account for the clinical effect seen. Likewise, the benefits of Yokukansan are probably attributable to the preparation as a whole, rather than to individual compounds. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：1265 / 1270

页数：6

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