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Enhancement of NO production in activated macrophages in vivo by an antimalarial crude drug, Dichroa febrifuga

被引：51
作者：
Murata, K
Takano, F
Fushiya, S
Oshima, Y
机构：
[1] Tohoku Univ, Fac Pharmaceut Sci, Expt Stn Med Plant Studies, Aoba Ku, Sendai, Miyagi 98077, Japan
[2] Tohoku Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Aoba Ku, Sendai, Miyagi 98077, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 06期
关键词：
D O I：
10.1021/np970433o
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The effect of an antimalarial crude drug, Dichroa febrifuga Lour. on nitric oxide (NO) production in bacillus Calmette Guerin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated. The NO production was significantly enhanced by an oral administration of a MeOH extract of D. febrifuga. Febrifugine (1) was isolated as the main active compound, and the activation was dose-dependent in the dosage range of 0.1-1 mg/kg/day.
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页码：729 / 733
页数：5
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