Enhancement of NO production in activated macrophages in vivo by an antimalarial crude drug, Dichroa febrifuga

被引：51

作者：

Murata, K

Takano, F

Fushiya, S

Oshima, Y

机构：

[1] Tohoku Univ, Fac Pharmaceut Sci, Expt Stn Med Plant Studies, Aoba Ku, Sendai, Miyagi 98077, Japan

[2] Tohoku Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Aoba Ku, Sendai, Miyagi 98077, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 06期

关键词：

D O I：

10.1021/np970433o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effect of an antimalarial crude drug, Dichroa febrifuga Lour. on nitric oxide (NO) production in bacillus Calmette Guerin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated. The NO production was significantly enhanced by an oral administration of a MeOH extract of D. febrifuga. Febrifugine (1) was isolated as the main active compound, and the activation was dose-dependent in the dosage range of 0.1-1 mg/kg/day.

引用

页码：729 / 733

页数：5

共 27 条

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