Chemoproteomics quantifies complexity

被引:3
作者
Holson, Edward B. [1 ]
Schreiber, Stuart L. [1 ]
机构
[1] Broad Inst Harvard & MIT, Cambridge, MA USA
关键词
INHIBITORS; RAPAMYCIN;
D O I
10.1038/nbt.1804
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The affinities of small molecules for proteins in megadalton complexes can be measured by mass spectrometry.
引用
收藏
页码:235 / 236
页数:3
相关论文
共 9 条
[1]   Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors [J].
Bantscheff, Marcus ;
Eberhard, Dirk ;
Abraham, Yann ;
Bastuck, Sonja ;
Boesche, Markus ;
Hobson, Scott ;
Mathieson, Toby ;
Perrin, Jessica ;
Raida, Manfred ;
Rau, Christina ;
Reader, Valerie ;
Sweetman, Gavain ;
Bauer, Andreas ;
Bouwmeester, Tewis ;
Hopf, Carsten ;
Kruse, Ulrich ;
Neubauer, Gitte ;
Ramsden, Nigel ;
Rick, Jens ;
Kuster, Bernhard ;
Drewes, Gerard .
NATURE BIOTECHNOLOGY, 2007, 25 (09) :1035-1044
[2]   Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes [J].
Bantscheff, Marcus ;
Hopf, Carsten ;
Savitski, Mikhail M. ;
Dittmann, Antje ;
Grandi, Paola ;
Michon, Anne-Marie ;
Schlegl, Judith ;
Abraham, Yann ;
Becher, Isabelle ;
Bergamini, Giovanna ;
Boesche, Markus ;
Delling, Manja ;
Duempelfeld, Birgit ;
Eberhard, Dirk ;
Huthmacher, Carola ;
Mathieson, Toby ;
Poeckel, Daniel ;
Reader, Valerie ;
Strunk, Katja ;
Sweetman, Gavain ;
Kruse, Ulrich ;
Neubauer, Gitte ;
Ramsden, Nigel G. ;
Drewes, Gerard .
NATURE BIOTECHNOLOGY, 2011, 29 (03) :255-U124
[3]   Histone deacetylase 1 and 2-controlled embryonic development and cell differentiation [J].
Brunmeir, Reinhard ;
Lagger, Sabine ;
Seiser, Christian .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2009, 53 (2-3) :275-289
[4]   Chromatin remodeling, cancer and chemotherapy [J].
Dey, Pranab .
CURRENT MEDICINAL CHEMISTRY, 2006, 13 (24) :2909-2919
[5]   Interaction with AKAP79 Modifies the Cellular Pharmacology of PKC [J].
Hoshi, Naoto ;
Langeberg, Lorene K. ;
Gould, Christine M. ;
Newton, Alexandra C. ;
Scott, John D. .
MOLECULAR CELL, 2010, 37 (04) :541-550
[6]   Therapeutic application of histone deacetylase inhibitors for central nervous system disorders [J].
Kazantsev, Aleksey G. ;
Thompson, Leslie M. .
NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (10) :854-868
[7]   Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton [J].
Sarbassov, DD ;
Ali, SM ;
Kim, DH ;
Guertin, DA ;
Latek, RR ;
Erdjument-Bromage, H ;
Tempst, P ;
Sabatini, DM .
CURRENT BIOLOGY, 2004, 14 (14) :1296-1302
[8]   A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p [J].
Taunton, J ;
Hassig, CA ;
Schreiber, SL .
SCIENCE, 1996, 272 (5260) :408-411
[9]   TOR KINASE DOMAINS ARE REQUIRED FOR 2 DISTINCT FUNCTIONS, ONLY ONE OF WHICH IS INHIBITED BY RAPAMYCIN [J].
ZHENG, XF ;
FIORENTINO, D ;
CHEN, J ;
CRABTREE, GR ;
SCHREIBER, SL .
CELL, 1995, 82 (01) :121-130