Cerebellar cognitive affective syndrome associated with topiramate

被引：15

作者：

Baillieux, Hanne ^{[3
]}

Verslegers, Werner ^{[4
]}

Paquier, Philippe ^{[3
,5
,6
]}

De Deyn, Peter P. ^{[1
,2
]}

Marien, Peter ^{[1
,2
,3
]}

机构：

[1] Univ Antwerp, ZNA Middelheim, Dept Neurol, B-2020 Antwerp, Belgium

[2] Univ Antwerp, Inst Born Bunge, Lab Neurochem & Behav, B-2020 Antwerp, Belgium

[3] Vrije Univ Brussel, Dept Linguist, Brussels, Belgium

[4] ZNA Jan Palfijn, Dept Neurol, Antwerp, Belgium

[5] Univ Antwerp, Hop Univ Erasme ULB, Dept Neurol, Brussels, Belgium

[6] Univ Antwerp, Unit Neurosci, Brussels, Belgium

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2008年 / 110卷 / 05期

关键词：

topiramate; cognitive affective syndrome; epilepsy; cognition; behavior; cerebellum; SPECT;

D O I：

10.1016/j.clineuro.2008.01.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The cerebellar cognitive affective syndrome (CCAS) represents a spectrum of cerebellar-induced neurocognitive and affective disturbances. In this report a patient is described who developed CCAS under a treatment with standard daily dose of the anti-epileptic drug topiramate (TPM). Cognitive disturbances consisted of impaired visuo-spatial memory, concentration deficits and executive dysfunctions. Behavior and affect were characterized by marked mood-swings and several disinhibited symptoms. After a gradual discontinuation of treatment with topiramate, a complete remission of the cognitive and affective symptoms was observed within 6 weeks. Functional neuroimaging studies by means of SPECT were conducted 2 weeks and 8 months following TPM discontinuation. This case report seems to suggest that functional disruption of the cerebello-cerebral circuitry, leading to CCAS, can follow treatment with topiramate. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：496 / 499

页数：4

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