Nucleotide sequence and expression of rat β-defensin-1:: Its significance in diabetic rodent models

被引：20

作者：

Hiratsuka, T ^{[1
]}

Nakazato, M ^{[1
]}

Date, Y ^{[1
]}

Mukae, H ^{[1
]}

Matsukara, S ^{[1
]}

机构：

[1] Miyazaki Med Coll, Dept Internal Med 3, Miyazaki 8891692, Japan

来源：

NEPHRON | 2001年 / 88卷 / 01期

关键词：

rat beta-defensin-1; antimicrobial peptide; cDNA; diabetic rodent model; urinary tract infection;

D O I：

10.1159/000045961

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

beta -Defensins are epithelium-derived antimicrobial peptides that function in the host's innate defense. We identified the first member of the rat beta -defensin family, beta -defensin-1 (BD-1), in the kidney and determined its nucleotide sequence. It was predicted to be a 37-amino-acid peptide. Rat BD-1 mRNA was expressed most abundantly in the kidney, next in skin, tongue, esophagus, and uterus, followed (at low levels) by brain, trachea, stomach, urinary bladder, and ovary. BD-1 gene expression in rat kidney was not increased by lipopolysaccharide administration. BD-1 gene expressions in the kidneys of diabetic rodent models, cholecystokinin-insensitive Otsuka Long-Evans Tokushima Fatty rats, leptin-insensitive obese (fa/fa) Wistar rats, and db/db mice, were significantly lower than those of their lean littermates. BD-1 reduction may be in part responsible for the high incidence of urinary tract infections in diabetes mellitus. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：65 / 70

页数：6

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