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Cyclin T2A gene maps on human chromosome 2q21

被引：16
作者：
De Luca, A
Tosolini, A
Russo, P
Severino, A
Baldi, A
De Luca, L
Cavallotti, I
Baldi, F
Giordano, A
Testa, JR
Paggi, MG
机构：
[1] Regina Elena Inst Canc Res, Lab Cell Metab & Pharmacokinet, Ctr Expt Res, CRS, I-00158 Rome, Italy
[2] Univ Naples 2, Sch Med, Inst Top Anat, Naples, Italy
[3] Fox Chase Canc Ctr, Program Mol Oncol, Philadelphia, PA 19111 USA
[4] Univ Naples 2, Dept Biochem & Biophys F Cedrangolo, Sect Anat Pathol, Naples, Italy
[5] Thomas Jefferson Univ, Jefferson Med Coll, Dept Pathol, Philadelphia, PA 19107 USA
[6] Thomas Jefferson Univ, Jefferson Med Coll, Dept Anat, Philadelphia, PA 19107 USA
[7] Thomas Jefferson Univ, Jefferson Med Coll, Dept Cell Biol, Philadelphia, PA 19107 USA
来源：
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2001年 / 49卷 / 06期
关键词：
cyclin T2a; immunohistochemistry; chromosome; 2q21; FISH; skeletal muscle; myopathy;
D O I：
10.1177/002215540104900603
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cyclin T2a was recently identified as one of the regulatory subunits of the cdk-cyclin complex P-TEFb, the most studied positive factor in the regulation of transcription elongation. By fluorescent in situ hybridization (FISH), the gene codifying for cyclin T2a has been mapped on human chromosome 2q21. This locus also has been linked to different forms of myopathy. By use of a new specific antiserum raised against cyclin T2a, the immunohistochemical pattern of expression of cyclin T2a in human tissues has been examined and compared to that of cyclin T1, described in the previous report. The observation that immunohistochemical expression of cyclin T2a was high in skeletal muscle cells, whereas it was undetectable in two cases of centronuclear myopathy, together with its chromosomal location, suggests an involvement of the cdk9-cyclin T2a complex in this disease.
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收藏
页码：693 / 697
页数：5
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