Dynamic biosynthesis of heparan sulphate sequences in developing mouse brain: a potential regulatory mechanism during development

被引:14
作者
Guimond, S
Turner, K
Kita, M
Ford-Perriss, M
Turnbull, J
机构
[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
[2] Univ Melbourne, Dept Anat & Cell Biol, Melbourne, Vic 3010, Australia
关键词
heparanome; proteoglycan; sulphotransferase;
D O I
10.1042/0300-5127:0290177
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Over recent years our understanding of the functions of the heparan sulphate (HS) family of complex polysaccharides has shifted dramatically. Once seen as simply structural scaffolding in the extracellular matrix, they are now viewed as critical players in the regulatory network of cells. They are strategically located at the cell surface and in the extracellular matrix, and there has been an increasing realization that specific sequences in the HS chains are designed for selective interactions with many proteins. Functionally, these interactions result in regulation of the protein activities. It is becoming clear that HS functions as a new class of multifunctional cell regulator. There is also growing evidence that cells can dynamically alter the structure of HS sequences that they express. Here we review recent developments and describe evidence for regulated changes in the synthesis and structure of HS chains expressed during early mouse brain development. The data suggest a new concept in which dynamic changes in biosynthesis of different HS sequences create distinct cellular HS repertoires, the heparanome [1]. Their expression, in specific spatio-temporal patterns, is likely to endow organisms with novel regulatory mechanisms for controlling the activity of specific MS-binding proteins.
引用
收藏
页码:177 / 181
页数:5
相关论文
共 37 条
[21]   Biosynthesis of heparin/heparan sulfate - DNA cloning and expression of D-glucuronyl C5-epimerase from bovine lung [J].
Li, JP ;
HagnerMcWhirter, A ;
Kjellen, L ;
Palgi, J ;
Jalkanen, M ;
Lindahl, U .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) :28158-28163
[22]   The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate [J].
Lind, T ;
Tufaro, F ;
McCormick, C ;
Lindahl, U ;
Lidholt, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (41) :26265-26268
[23]   Regulated diversity of heparan sulfate [J].
Lindahl, U ;
Kusche-Gullberg, M ;
Kjellén, L .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (39) :24979-24982
[24]   Domain structure of heparan sulfates from bovine organs [J].
Maccarana, M ;
Sakura, Y ;
Tawada, A ;
Yoshida, K ;
Lindahl, U .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (30) :17804-17810
[25]   Heparin sequencing brings structure to the function of complex oligosaccharides [J].
Nugent, MA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10301-10303
[26]   Cell surface heparan sulfate proteoglycans: Selective regulators of ligand-receptor encounters [J].
Park, PW ;
Reizes, O ;
Bernfield, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (39) :29923-29926
[27]   Specificities of heparan sulphate proteoglycans in developmental processes [J].
Perrimon, N ;
Bernfield, M .
NATURE, 2000, 404 (6779) :725-728
[28]  
Raballo R, 2000, J NEUROSCI, V20, P5012
[29]  
SANDERSON RD, 1994, J BIOL CHEM, V269, P13100
[30]   BASIC FIBROBLAST GROWTH-FACTOR CONTROLS THE EXPRESSION AND MOLECULAR-STRUCTURE OF HEPARAN-SULFATE IN CORNEAL ENDOTHELIAL-CELLS [J].
SCHMIDT, A ;
SKALETZROROWSKI, A ;
BUDDECKE, E .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 234 (02) :479-484