Identification and ecdysteroid antagonist activity of three resveratrol trimers (suffruticosols A, B and C) from Paeonia suffruticosa

被引：68

作者：

Sarker, SD

Whiting, P

Dinan, L ^{[1
]}

Sik, V

Rees, HH

机构：

[1] Univ Exeter, Dept Biol Sci, Hatherly Labs, Exeter EX4 4PS, Devon, England

[2] Univ Exeter, Dept Chem, Exeter EX4 4QD, Devon, England

[3] Univ Liverpool, Sch Biol Sci, Liverpool L69 7ZB, Merseyside, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0040-4020(98)01049-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-guided HPLC analysis of the seeds of Paeonia suffruticosa has afforded three navel resveratrol trimers (suffruticosol A, suffruticosol B and suffruticosol C), together with cis-resveratrol and paeoniflorin. The structures of these new compounds have been elucidated mainly by comprehensive 1D- and ZD-NMR experiments. Resveratrol and its oligomers are active as ecdysteroid antagonists (ED50 values = 10 to 50 mu M vs. 5 x 10(-8)M 20-hydroxyecdysone) in the Drosophila melanogaster Bn bioassay. The activities of other "pseudo-oestrogens" in this bioassay have also been assessed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：513 / 524

页数：12

共 33 条

[1] CANALICULATOL, AN ANTIFUNGAL RESVERATROL TRIMER FROM STEMONOPOROUS-CANALICULATUS [J].