Synthesis of novel acridino- and phenazino-18-crown-6 ligands and their optically pure dimethyl-substituted analogues for molecular recognition studies

被引：46

作者：

Huszthy, P ^{[1
]}

Samu, E

Vermes, B

Mezey-Vándor, G

Nógrádi, M

Bradshaw, JS

Izatt, RM

机构：

[1] Hungarian Acad Sci, Res Grp Alkaloid Chem, H-1521 Budapest, Hungary

[2] Tech Univ Budapest, Inst Organ Chem, H-1521 Budapest, Hungary

[3] Brigham Young Univ, Dept Chem, Provo, UT 84602 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 05期

关键词：

acridines; crown ethers; molecular recognition; phenazines;

D O I：

10.1016/S0040-4020(98)01128-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel acridino- and phenazino-18-crown-6 ligands 5 and 6 were I,prepared from acridine-4.5-diol (9) and phenazine-1,9-diol (10) with tetraethylene glycol di-p-tosylate (11) using potassium tert-butoxide as a bar in THF. New optically pure dimethyl-substituted acridino- and phenazine-18-crown-6 ligands (R,R)-7 and (R,R)-8 were also prepared by treating 9 and 10 with optically pure dimethyl-substituted tetraethylene glycol di-p-tosylate [(S,S)-18], Molecular recognition studies on these novel ligands are underway. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1491 / 1504

页数：14

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