Catalytic asymmetric synthesis of cyclopropylphosphonates - Catalysts' scope and reactivity

被引：21

作者：

Charette, AB ^{[1
]}

Bouchard, JE ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

CANADIAN JOURNAL OF CHEMISTRY | 2005年 / 83卷 / 6-7期

关键词：

cyclopropylphosphonic acids; copper catalysts; ruthenium catalysts; cyclopropanation; diazo reagents;

D O I：

10.1139/v05-074

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The transition metal- catalyzed cyclopropanation of alkenes using alpha- diazomethylphosphonates leads to cyclopropylphosphonate derivatives in high yields. The reaction proceeds well with copper, rhodium, and ruthenium catalysts. The best catalysts for the enantioselective version are either Evans' Cu center dot bis( oxazoline) or Nishiyama's Ru center dot pybox.

引用

页码：533 / 542

页数：10

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