Highly enantioselective synthesis of cyclopropylphosphonates catalyzed by chiral ruthenium porphyrins

被引：64

作者：

Ferrand, Y ^{[1
]}

Le Maux, P ^{[1
]}

Simonneaux, G ^{[1
]}

机构：

[1] Univ Rennes 1, Inst Chim, Lab Chim Organomet & Biol, UMR 6509, F-35042 Rennes, France

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 18期

关键词：

D O I：

10.1021/ol048567y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric addition of diisopropyl diazomethylphosphonate to styrene derivatives was carried out by using chiral ruthenium porphyrins as catalysts. The reaction proceeded under mild conditions and gave trans-cyclopropylphosphonates with good yields and high ee's (up to 92%). A progressive increase for stereochemical effectiveness exists between enantiomeric excess and the number of chiral goups linked to ruthenium porphyrins.

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页码：3211 / 3214

页数：4

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